I say I'm lesbian to save time, but if I were to break it down, I'm lesbian-pansexual. 99.95% interested in women, genetic or transgender. The other .05% is guys. Its a very, very, very small possibility I could take interest romantically in a guy. Not impossible, but also not all that probable. It just is what it is.
At the end of the day, what matters is if the presentation of those characters came across and possibly even helped people. Turns out that's the case with Kanji and Naoto in some instances. I'm not really all that interested in who is a "real" gay character, but if their portray helps or changes perceptions. Some people think Cortez in ME3 was an eye-opener. I don't but who am I to complain if that helped them change their tune?