I know Mark II is supposed to protect against a wide array of things but I've never seen it happen personally. Still, I've seen missiles and attack drones get struck down by lasers so anything might be possible. Course depending on what system it targets it might as well be impossible.
I've had lasers knock out Hacking droids. If they collide with other projectiles they'll go down, so it's more of just a luck thing. I believe that the Mark II does not specifically fire at incoming hacking droids, but if the laser it shoots happens to collide with it first instead of its intended target, it'll probably destroy it.