I saw this the other day and got totally stoked:
LEGOs and Mass Effect. It just sounds fantastic to me. And it got me thinking of what other supremely awesome crossovers there could be. I know this route has already been taken with Star Wars, Harry Potter, and all that crap, but what are the chances that they'd want to work with a rated-M game? Thus, it's cool.
So how about it? Playmobile Uncharted? My Little Pony Gears of War? COMMENCE!
credit for the art goes to Either-Art from Deviant Art. Art.